Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.

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736 – 750 of 4,546 results

736

Medchemexpress LLC Dabigatran ethyl ester hydrochloride | 211914-50-0 | 99.4% | C27H30ClN7O3 | 1 ML

Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2) with an IC50 value of 0.8 μM. It also functions as a thrombin inhibitor. The ethyl ester group enhances interaction with hydrophobic amino acids, contributing to its higher affinity for both thrombin and NQO2 compared to Dabigatran. This compound is a selective, reversible, and potent thrombin inhibitor, orally available as the prodrug, dabigatran etexilate.

Potent inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2)
Thrombin inhibitor
Higher affinity for thrombin and NQO2 compared to Dabigatran
Selective and reversible thrombin inhibitor
Orally available as the prodrug dabigatran etexilate
For research use only

Pricing & Availability

737

Medchemexpress LLC Benzonitrile, 4,4'-(hydroxymethylene)bis- | 134521-16-7 | 234.25 | 1 ML

CGP 44 645 is the methanol metabolite of Letrozole. It serves as a molecular indicator for evaluating the metabolic kinetics of Letrozole in microsomes in vitro, with levels in rat liver microsomes potentially being sex-specific.

For research use only
Metabolic enzyme/protease drug metabolite
Molecular indicator for evaluating metabolic kinetics in microsomes in vitro
Soluble in DMSO (≥ 200 mg/mL)

Pricing & Availability

738

Medchemexpress LLC 1H-Indole, 3-(2-chloro-4-pyrimidinyl)-1-methyl- | 1032452-86-0 | 99.5% | C13H10ClN3 | 100 G

3-(2-Chloropyrimidin-4-yl)-1-methylindole (MedChemExpress HY-78866) is a high-purity chemical compound, appearing as an off-white to light yellow solid. With a molecular weight of 243.70 and a purity of 99.5%, it is suitable for various research applications.

Appearance: Off-white to light yellow solid
Purity: 99.5%
Powder storage stability: 3 years at -20°C, 2 years at 4°C
In solvent storage stability: 6 months at -80°C, 1 month at -20°C

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739

Medchemexpress LLC 2(1H)-Quinolinone, 7-amino-4-methyl- | 19840-99-4 | 174.20 | 250 MG

Carbostyril 124 is a sensitising chromophore that acts as a reasonably effective organic sensitizer for a proximate bound terbium ion. It is exclusively for research use.

Sensitising chromophore
Functions as an organic sensitizer for terbium ions
Exhibits metal-based luminescence with europium and terbium complexes
Intended for research use only

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740

Medchemexpress LLC Methyl cyclohexanecarboxylate | 4630-82-4 | 142.20 | 5 G

Methyl cyclohexanecarboxylate is an endogenous metabolite.

Intended for research use only
Colorless to light yellow liquid appearance
Soluble in DMSO (requires ultrasonic treatment)
Available in various sizes
Can be stored at -20°C for 3 years or 4°C for 2 years in pure form
Stock solutions in solvent should be aliquoted to prevent freeze-thaw inactivation
Key applications include natural products disease research and metabolic studies

Pricing & Availability

741

Medchemexpress LLC Hexadecyltrimethylammonium tetrafluoroborate | 73257-08-6 | MFCD00144896 | >98.0% | 371.35 g·mol⁻¹ | C19H42BF4N | 250 MG

Hexadecyltrimethylammonium tetrafluoroborate is a quaternary ammonium salt used as a biochemical reagent and phase-transfer surfactant in laboratory research. It is typically supplied as a white to off-white solid (formula C19H42BF4N; molecular weight 371.35 g·mol⁻¹) in small pack sizes for analytical and synthetic work. Handle according to the SDS for quaternary ammonium compounds.

Quaternary ammonium surfactant for phase-transfer and interfacial chemistry.
Suitable for biochemical assays and general laboratory research.
Available in small pack sizes suitable for analytical work, including 250 mg.
Reported high purity for reproducible results; verify exact purity on the SDS.
White to off-white solid that is easy to weigh and store under recommended conditions.

Pricing & Availability

742

Medchemexpress LLC 4-Aminobutylphosphonic acid | 35622-27-6 | MFCD00063426 | 98.0% | 153.12 g/mol | C4H12NO3P | 250 MG

4-Aminobutylphosphonic acid is a phosphonic acid-containing amino acid derivative intended for research use where stable phosphonate analogs of amino acids are required. Supplied as a solid powder, it is suitable for biochemical and enzymatic studies involving phosphonate chemistry.

High purity: 98.0%.
Molecular formula C4H12NO3P; molecular weight 153.12 g/mol.
Solid powder appearance, typically white to gray.
Recommended storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
Available pack sizes include 250 mg, 1 g, 5 g, 10 g, and 50 g.
Useful as a phosphonate analog in biochemical and enzymatic research.

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743

Medchemexpress LLC Salubrinal | 405060-95-9 | C21H17Cl3N4OS | 250 MG

Salubrinal | 405060-95-9 | C21H17Cl3N4OS | 250 MG

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744

Medchemexpress LLC 3-Azidopropylamine | 88192-19-2 | MFCD11046568 | C3H8N4 | 250 MG

3-Azidopropylamine is a click chemistry reagent containing an azide group. It is utilized for the complexation and transfection of plasmid DNA by reacting with the starch sugar of potato starch. This reagent facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules and can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing DBCO or BCN groups.

Click chemistry reagent
Contains an azide group
Reacts with starch sugar for complexation and transfection of plasmid DNA
Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Participates in ring strain-promoted alkyne-azide cycloaddition (SPAAC)

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745

Medchemexpress LLC Ethyl ferulate | 4046-02-0 | 99.9% | 222.24 | 5 G

Ethyl ferulate is a naturally occurring lipophilic derivative of ferulic acid, originally found in Rhizoma Chuanxiong. It induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress. It also protects neurons from amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity.

Induces heme oxygenase-1 (HO-1)
Protects rat neurons against oxidative stress
Protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity
Inhibits LPS-induced acute lung injury in mice
Inhibits retinal neovascularization in oxygen-induced retinopathy mice model
Increases Nrf-2 expression and nuclear translocation
Decreases Keap-1 expression, and increases HO-1 and NQO-1 expression
Reduces hypoxia-induced HIF-1α and VEGFA expression

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746

Medchemexpress LLC Urocortin, rat | 171543-83-2 | 96.6% | 4707.26 | 250 MG

Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenous CRFR agonist with Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively. It is intended for research use only.

Potent endogenous CRFR agonist.
Kis of 13 nM, 1.5 nM, and 0.97 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively.
Induces cyclic AMP (cAMP) generation with EC50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively in stably transfected Chinese hamster ovary cells.
Decreases food intake in both food-deprived and non-deprived rats (0.01 to 10 μg) and mice (1 μg i.c.v. administration).
Potential for inducing anxiogenic behavior.

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747

Medchemexpress LLC Ethyl arachidonate | 1808-26-0 | 98.3% | 332.52 | 10 MG

Ethyl arachidonate is a lipophilic esterified form of arachidonic acid (AA). It can be used in dietary regimens or fed to cultured cells as a source of exogenous arachidonate. It is also the main species of fatty acid ethyl esters (FAEE) found in the brain of alcohol-intoxicated subjects.

Lipophilic esterified form of arachidonic acid
Can be incorporated into dietary regimens
Can be fed to cultured cells as a source of exogenous arachidonate
Primary fatty acid ethyl ester (FAEE) found in the brains of alcohol-intoxicated subjects
Research use only

Pricing & Availability

748

Medchemexpress LLC Ethyl 3-hydroxybutyrate | 5405-41-4 | 100.0% | 132.16 | 10 G

Ethyl 3-hydroxybutyrate is a fragrance found in wine and Tribolium castaneum. It has shown potential in alleviating skeletal muscle wasting in cancer cachexia by increasing 3-HB levels in serum, promoting the TCA cycle and protein synthesis, improving metabolic homeostasis, reducing inflammation, and enhancing antioxidant capacity.

Increases 3-HB levels in serum.
Promotes TCA cycle and protein synthesis.
Improves metabolic homeostasis.
Reduces inflammation responses.
Enhances antioxidant capacity.
Alleviates cancer cachexia-associated skeletal muscle atrophy.

Pricing & Availability

749

Medchemexpress LLC Arborinine | 5489-57-6 | 99.9% | 250 MG

Arborinine is a potent and orally active LSD1 inhibitor, demonstrating significant antitumor activity. It operates by increasing the expression of H3K4me1/2, H3K9me1/2, and E-cad protein, while concurrently decreasing the expression of UBE2O protein levels. Arborinine has been shown to induce cell cycle arrest at the S phase and inhibit cell apoptosis. Its antiproliferative effects have been observed in various cell lines, including 7860, A498, 769P, Caki1, and OSRC2 cells. Furthermore, in in vivo studies, Arborinine exhibited antitumor activity in mouse models by inhibiting tumor growth without affecting body weight.

Potent LSD1 inhibitor.
Orally active.
Modulates gene expression: increases the expression of H3K4me1/2, H3K9me1/2, and E-cad protein.
Decreases UBE2O protein level.
Induces cell cycle arrest at the S phase.
Inhibits apoptosis.
Antitumor activity.

Pricing & Availability

750

Medchemexpress LLC N2,N2-Dimethylguanosine | 2140-67-2 | 99.4% | 311.29 | 50 MG

N2,N2-Dimethylguanosine is a methylated nucleoside present in RNA and a structural modification component of tRNA. It hinders reverse transcriptase-mediated cDNA synthesis and is a key modification affecting sequencing efficiency in high-throughput RNA sequencing. It can be selectively demethylated into N2-methylguanosine by AlkB mutant enzymes (such as D135S/L118V), reducing hindrance to reverse transcription.

Methylated nucleoside present in RNA and a structural modification component of tRNA.
Hinders reverse transcriptase-mediated cDNA synthesis.
Key modification affecting sequencing efficiency in high-throughput RNA sequencing.
Can be converted to N2-methylguanosine by AlkB mutant enzymes to reduce hindrance to reverse transcription.
Appears as a white to off-white solid.
Initial source: Endogenous metabolite.

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Pyrimidines And Derivatives

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Medchemexpress LLC Dabigatran ethyl ester hydrochloride | 211914-50-0 | 99.4% | C27H30ClN7O3 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Benzonitrile, 4,4'-(hydroxymethylene)bis- | 134521-16-7 | 234.25 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1H-Indole, 3-(2-chloro-4-pyrimidinyl)-1-methyl- | 1032452-86-0 | 99.5% | C13H10ClN3 | 100 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2(1H)-Quinolinone, 7-amino-4-methyl- | 19840-99-4 | 174.20 | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Methyl cyclohexanecarboxylate | 4630-82-4 | 142.20 | 5 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Hexadecyltrimethylammonium tetrafluoroborate | 73257-08-6 | MFCD00144896 | >98.0% | 371.35 g·mol⁻¹ | C19H42BF4N | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 4-Aminobutylphosphonic acid | 35622-27-6 | MFCD00063426 | 98.0% | 153.12 g/mol | C4H12NO3P | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Salubrinal | 405060-95-9 | C21H17Cl3N4OS | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 3-Azidopropylamine | 88192-19-2 | MFCD11046568 | C3H8N4 | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ethyl ferulate | 4046-02-0 | 99.9% | 222.24 | 5 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Urocortin, rat | 171543-83-2 | 96.6% | 4707.26 | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ethyl arachidonate | 1808-26-0 | 98.3% | 332.52 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ethyl 3-hydroxybutyrate | 5405-41-4 | 100.0% | 132.16 | 10 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Arborinine | 5489-57-6 | 99.9% | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N2,N2-Dimethylguanosine | 2140-67-2 | 99.4% | 311.29 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More